Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease - Depression, Inflammation, and Clustering of Metabolic Risk Markers -full text

Abstract

Objective:

To understand why children exposed to adverse psychosocial experiences are at elevated risk for age-related disease, such as cardiovascular disease, by testing whether adverse childhood experiences predict enduring abnormalities in stress-sensitive biological systems, namely, the nervous, immune, and endocrine/metabolic systems....

Conclusions:

Children exposed to adverse psychosocial experiences have enduring emotional, immune, and metabolic abnormalities that contribute to explaining their elevated risk for age-related disease. The promotion of healthy psychosocial experiences for children is a necessary and potentially cost-effective target for the prevention of age-related disease.

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Danese, et al. (2009). "Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease - Depression, Inflammation, and Clustering of Metabolic Risk Markers." Arch Pediatr Adolesc Med.,163(12):1135-1143.