Effects of the Adverse Life Events and Disrupted in Schizophrenia-1 (DISC1) Gene Polymorphisms on Acute Symptoms of Schizophrenia - abstract

Chris Engel 1/27/134:00 PM

Abstract

The aim of this study was to evaluate the effects of traumatic childhood events and recent adverse life events, as well as the Disrupted in Schizophrenia-1 (DISC1) gene polymorphisms on types of last acute symptoms of patients with schizophrenia. Hundred patients with schizophrenia were given the Childhood Trauma Questionnaire, the Social Readjustment Rating Scale, Scale for Assessment of Positive Symptoms (SAPS), Scale for Assessment of Negative Symptoms (SANS), Brief Psychiatric Rating Scale (BPRS), and Calgary Depression Scale for Schizophrenia (CDSS)....This study shows that features of acute symptoms in schizophrenia are not influenced by the polymorphisms on the DISC1 gene, but are influenced by recent adverse life events and emotional abuse at childhood.

http://www.ncbi.nlm.nih.gov/pubmed/23347445

Sayin, et al. DNA Cell Biol. 2013 Feb;32(2):73-80. doi: 10.1089/dna.2012.1894.

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