Major depression is a serious mood disorder that affects around 1 in 6 people during their lifetime.
When it occurs, persistent feelings of sadness, frustration, loss or anger disrupt everyday life and can endure for weeks, months or even years.
The hippocampus - whose name comes from the Ancient Greek word for "seahorse" because of its shape - is an area of the brain that, among other things, is associated with forming new memories.
The ENIGMA study researchers, including a group from the Brain and Mind Research Institute (BMRI) at the University of Sidney in Australia, suggest their findings highlight a need to treat depression when it first occurs - especially in adolescents and young adults.
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