Hispanic women with prediabetes and overweight or obesity who were assigned to an intensive lifestyle intervention for 1 year experienced a greater reduction in body weight if their mental health remained stable or improved vs. similar women whose mental health worsened during the same time, study data show.
“We found that all participants lost weight in the first 6 months, regardless of changes in their mental health measures,” Matthew O’Brien, MD, MSc, assistant professor of medicine and preventive medicine at Northwestern University’s Feinberg School of Medicine, told Endocrine Today. “However, weight trajectories diverged from 6 to 12 months, with weight regain among participants whose mental health worsened and continued weight loss among those whose mental health was improved or stable.”
O’Brien and colleagues analyzed data from 92 Hispanic women with prediabetes and overweight or obesity assigned to a group-based intensive lifestyle intervention (n = 33; mean age, 46 years; mean BMI, 34.4 kg/m²), 850 mg metformin twice daily (n = 29; mean age, 45 years; mean BMI, 32.7 kg/m²) or standard care (n = 30; mean age, 45 years; mean BMI, 32.2 kg/m²) for 12 months, as part of PREVENT-DM, a comparative effectiveness trial based on the Group Lifestyle Balance Program. Women assigned to the intensive lifestyle intervention attended 14 weekly sessions, followed by 10 biweekly or monthly sessions. Women in the metformin arm attended brief monthly study visits; women in the standard care arm attended two study visits over 12 months, in which they received written educational materials about diabetes prevention. Participants completed three questionnaires to measure mental health variables: Beck Depression Inventory (depression severity scores range from 0 to 28), Generalized Anxiety Disorder scale (anxiety severity score ranges from 0 to 21) and Perceived Stress Scale (perceived stress score ranges from 0 to 40). Primary outcome was weight change from baseline to 12 months and its association with changes in depression, anxiety and perceived stress. Women whose symptom scores worsened on any one of the of the three measures were considered to have worsened mental health; those whose scores improved or remained stable on all three measures were considered to have improved or stable mental health.
[For more on this story by Matthew O'Brien, go to https://www.healio.com/endocri...festyle-intervention]
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