Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine - abstract
Abstract Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that erasure of CpG methylation (5mC) in PGCs occurs via conversion to...